Premature aging
Premature Aging
Premature aging (pronunciation: /priːˈmeɪtʃər ˈeɪdʒɪŋ/), also known as Progeria, is a rare genetic condition that results in a child's body aging rapidly. The term is derived from the Greek words 'pro' (meaning 'before') and 'geras' (meaning 'old age').
Causes
Premature aging is primarily caused by a mutation in the LMNA (pronunciation: /ˈɛlˌɛmˈɛnˈeɪ/) gene. This gene produces the lamin A protein, which is crucial for maintaining the structural integrity of cells. When the LMNA gene is mutated, it leads to the production of an abnormal version of the lamin A protein, known as progerin.
Symptoms
Symptoms of premature aging include growth failure, loss of body fat and hair, aged-looking skin, stiffness of joints, hip dislocation, generalized atherosclerosis, cardiovascular (heart) disease and stroke. These symptoms resemble aspects of aging in the general population, but they occur in early childhood and progress rapidly.
Diagnosis
Diagnosis of premature aging is based on the characteristic symptoms and signs. Genetic testing can confirm the diagnosis by identifying the mutation in the LMNA gene.
Treatment
There is currently no cure for premature aging. Treatment is focused on managing the symptoms and may include low-dose aspirin to reduce the risk of stroke and heart attack, physical and occupational therapy to improve joint mobility and maintain independence, and high-calorie dietary supplements to improve weight gain and growth.
See Also
References
External links
- Medical encyclopedia article on Premature aging
- Wikipedia's article - Premature aging
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