In a point mutation, either:
- a single base nucleotide is changed for another nucleotide of the genetic material (normally DNA), or
- a single base pair is inserted or deleted.
A nonsense mutation is a point mutation in a DNA sequence that leads to an early stop codon. This appears as a nonsense codon in the transcribed mRNA. Most of the time, the protein that is translated from this mRNA does not work.
- Eldon D Enger; Frederick C Ross; David B Bailey, Concepts in Biology, 12th Edition (London: McGraw-Hill, 2007), p. 158
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