Phenyltoloxamine

Information about Phenyltoloxamine

Phenyltoloxamine is a first generation antihistamine that is used for symptoms of the common cold and as a short acting sedative.

Liver safety of Phenyltoloxamine

Phenyltoloxamine has not been linked to instances of clinically apparent acute liver injury.

Mechanism of action of Phenyltoloxamine

Phenyltoloxamine (fen" il tol ox' a meen) is a first generation antihistamine that is used to treat the symptoms of the common cold, including sneezing, cough, runny note, watery eyes and itching. Because of its sedating side effects, it is also used as a mild sleeping aid and sedative. Phenyltoloxamine belongs to the ethanolamine class of antihistamines (with clemastine and dimenhydrinate) and is currently used largely in combination with other agents such as phenylephrine and acetaminophen in over-the-counter products for relief of symptoms of the common cold and nighttime relief of minor aches and pains.

Brand name for Phenyltoloxamine

Representative brand names of products that include phenyltoloxamine include Dologesic and Relagesic.

Dosage and administration for Phenyltoloxamine

The typical adult oral dose is 30 to 50 mg.

Side effects of Phenyltoloxamine

Common side effects include sedation, impairment of motor function, confusion, dizziness, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Antihistamines can worsen urinary retention and glaucoma.

First Generation Antihistamines

• Brompheniramine
• Carbinoxamine
• Chlorcyclizine
• Chlorpheniramine
• Clemastine
• Cyclizine
• Cyproheptadine
• Dexbrompheniramine
• Dexchlorpheniramine
• Dimenhydrinate
• Diphenhydramine
• Doxylamine
• Hydroxyzine
• Meclizine
• Phenyltoloxamine
• Promethazine
• Triprolidine

Second Generation Antihistamines

• Acrivastine
• Cetirizine
• Fexofenadine
• Levocetirizine
• Loratadine
• Desloratadine

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