Palisaded encapsulated neuroma

Palisaded Encapsulated Neuroma

Palisaded Encapsulated Neuroma (Pronunciation: Pal-i-sad-ed En-cap-su-lat-ed N-u-ro-ma), also known as PEN or solitary circumscribed neuroma, is a benign neoplasm that primarily affects the dermis layer of the skin.

Etymology

The term "Palisaded Encapsulated Neuroma" is derived from the appearance of the tumor under the microscope. "Palisaded" refers to the arrangement of the nuclei of the Schwann cells that form a fence-like structure around the neuron, "Encapsulated" refers to the well-defined boundary of the tumor, and "Neuroma" refers to a tumor made up of nerve cells.

Description

Palisaded Encapsulated Neuroma is a rare, benign tumor that primarily affects the sensory nerves in the skin. It is characterized by a well-circumscribed, non-encapsulated mass of nerve tissue. The tumor is composed of proliferating Schwann cells and perineural cells, with the Schwann cells often arranged in a palisaded pattern.

Symptoms

The most common symptom of Palisaded Encapsulated Neuroma is a small, painless, firm nodule on the skin, usually less than 1 cm in diameter. The nodule is typically skin-colored or slightly reddish and is most commonly found on the face, particularly the nose. However, it can occur anywhere on the body.

Diagnosis

Diagnosis of Palisaded Encapsulated Neuroma is typically made through a biopsy of the affected tissue, followed by histopathological examination. The histopathological features of PEN include a well-circumscribed, non-encapsulated mass of nerve tissue, with the nerve cells often arranged in a palisaded pattern.

Treatment

Treatment for Palisaded Encapsulated Neuroma typically involves surgical removal of the tumor. Because the tumor is benign, it does not spread to other parts of the body, and removal is usually curative.

Related Terms

• Neoplasm
• Dermis
• Nuclei
• Schwann cells
• Neuron
• Tumor
• Perineural cells
• Biopsy
• Histopathological

External links

• Medical encyclopedia article on Palisaded encapsulated neuroma
• Wikipedia's article - Palisaded encapsulated neuroma

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