Paget
Paget's Disease
Paget's disease (pronounced: PAH-jets) is a medical condition that disrupts the normal cycle of bone renewal, causing them to become fragile and misshapen. The disease is named after Sir James Paget, a British surgeon and pathologist who first identified it in 1877.
Etymology
The term "Paget's disease" is derived from the name of Sir James Paget, who first described the condition. The term "disease" comes from the Old French desaise, meaning lack of ease, hardship, sickness, or trouble.
Types of Paget's Disease
There are two main types of Paget's disease:
- Paget's Disease of Bone: This is the most common form of the disease, affecting the bones. It can occur in any bone in the body, but most often it affects the spine, pelvis, skull, or leg bones.
- Paget's Disease of the Breast: Also known as Paget's disease of the nipple, this is a rare type of cancer that forms in or around the nipple and frequently extends to the areola.
Related Terms
- Osteoclast: A type of bone cell that breaks down bone tissue. This function is critical in maintaining, repairing, and remodeling bones in the body. Overactive osteoclasts can lead to Paget's disease of bone.
- Osteoblast: A type of cell that is responsible for forming new bone. In Paget's disease of bone, osteoblasts may be overactive, leading to the formation of bone that is weaker and less dense than normal.
- Pathology: The scientific study of disease. Sir James Paget was a pathologist, and his work in this field led to the discovery and naming of Paget's disease.
External links
- Medical encyclopedia article on Paget
- Wikipedia's article - Paget
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