PFA-100

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PFA-100

The PFA-100 (Platelet Function Assay-100) is a system used to measure platelet function. The PFA-100 is primarily used to diagnose platelet disorders and von Willebrand disease, and to monitor the effectiveness of antiplatelet therapy.

Pronunciation

PFA-100 is pronounced as "P-F-A-One-Hundred".

Etymology

The term PFA-100 is an acronym derived from Platelet Function Assay-100, indicating its use in assessing the function of platelets, which are crucial components in the blood clotting process.

Function

The PFA-100 system works by simulating the process of platelet adhesion and platelet aggregation, which are key steps in the formation of a blood clot. It does this by drawing blood through a small aperture under high shear conditions, mimicking the conditions that would occur in a damaged blood vessel.

Related Terms

  • Platelet: A type of blood cell that helps prevent bleeding by forming clots.
  • Platelet adhesion: The process by which platelets stick to the walls of damaged blood vessels.
  • Platelet aggregation: The process by which platelets clump together to form a clot.
  • Blood clot: A mass of platelets and other blood components that form to stop bleeding.
  • Von Willebrand disease: A genetic disorder that results in excessive bleeding due to defective blood clotting.
  • Antiplatelet therapy: Treatment with drugs that prevent platelets from clumping together to form clots.

External links

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