Oxybutynin

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Information about Oxybutynin

Oxybutynin is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.

Liver safety of Oxybutynin

Oxybutynin has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Mechanism of action of Oxybutynin

Oxybutynin (ox" i bue' ti nin) is synthetic anticholinergic that has specificity for the M1, M2 and M3 subtypes of the muscarinic acetylcholine receptor which are commonly found in bladder smooth muscle. Oxybutynin is used largely for the treatment of overactive bladder and for symptoms of frequency and urge incontinence.

FDA approval information for Oxybutynin

Oxybutynin was approved for use in the United States in 1975 and is still widely used. It is available in regular and extended release tablets as well as oral solutions, syrups, and transdermal creams in various generic forms and under the trade name Ditropan. A transdermal patch formulation is available under the brand name Oxytrol.

Dosage and administration for Oxybutynin

The usual adult oral dose is 10 to 20 mg daily in divided doses or in a single extended release tablet form.

Side effects of Oxybutynin

Common side effects are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, headache, visual blurring, constipation, urinary retention, impotence, tachycardia and palpitations, anxiety, restlessness and in some instances agitation and delusions. anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention.


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