Olsalazine

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Olsalazine

Olsalazine (pronounced ol-SAL-a-zeen) is a medication used in the treatment of ulcerative colitis, a chronic, inflammatory bowel disease. It is a prodrug that is split into two molecules of 5-ASA in the colon, where it exerts its anti-inflammatory effect.

Etymology

The name "Olsalazine" is derived from its chemical structure, which consists of two molecules of 5-aminosalicylic acid (5-ASA) linked together by an azo bond. The "ol" refers to the hydroxyl group in the 5-ASA molecule, "sal" refers to salicylic acid, and "azine" refers to the azo bond.

Usage

Olsalazine is used to treat mild to moderate ulcerative colitis when first-line treatments such as aminosalicylates are not effective. It is also used to maintain remission in patients with ulcerative colitis.

Mechanism of Action

As a prodrug, Olsalazine is inactive until it reaches the colon, where it is split by bacterial action into two molecules of 5-ASA. 5-ASA is a potent anti-inflammatory agent that works by inhibiting the production of prostaglandins and leukotrienes, substances that contribute to inflammation in the colon.

Side Effects

Common side effects of Olsalazine include diarrhea, abdominal pain, nausea, and headache. Rare but serious side effects include hepatitis, pneumonia, and myocarditis.

Related Terms

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