Noncompetitive inhibition

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Noncompetitive inhibition (pronunciation: non-kom-puh-ti-tiv in-hi-bi-shun) is a type of enzyme inhibition where the inhibitor does not compete with the substrate for the enzyme's active site; instead, it binds to another part of the enzyme, causing the enzyme to change shape and making the active site less effective at catalyzing the reaction.

Etymology

The term "noncompetitive inhibition" is derived from the fact that the inhibitor does not compete with the substrate for the enzyme's active site. The prefix "non-" means "not," "competitive" refers to competition, and "inhibition" refers to the process of inhibiting or preventing something.

Related Terms

  • Enzyme: A protein that acts as a catalyst to bring about a specific biochemical reaction.
  • Substrate: A molecule upon which an enzyme acts.
  • Active site: The region of an enzyme where substrate molecules bind and undergo a chemical reaction.
  • Inhibitor: A molecule that binds to an enzyme and decreases its activity.
  • Enzyme inhibition: The process by which an enzyme's activity is reduced by a molecule that binds to the enzyme.
  • Competitive inhibition: A form of enzyme inhibition where binding of the inhibitor to the active site on the enzyme prevents binding of the substrate and vice versa.

See Also

External links

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