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Nilutamide

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Information about Nilutamide

Nilutamide is an oral nonsteroidal antiandrogen similar in structure to flutamide that is used widely in the therapy of prostate cancer.

Liver safety of Nilutamide

Nilutamide has been linked to rare instances of liver injury

Mechanism of action of Nilutamide

Nilutamide (nye loo' ta mide) is an anilide that blocks the binding of endogenous androgens to intracellular androgen receptors blocking their effects and is used to treat prostate cancer.  Nilutamide has been shown to be effective in reducing pain and disease progression in metastatic prostate cancer when administered in conjunction with orchiectomy or other antiandrogen agents such as luteinizing hormone releasing hormone (LHRH) agonists. 

FDA approval information for Nilutamide

Nilutamide was approved for use in the United States in 1996. 

Clinical use of Nilutamide

Current indications are limited to the therapy of metastatic prostate cancer in combination with orchiectomy. 

Dosage and administration for Nilutamide

Nilutamide is available under the trade name Nilandron in 150 mg tablets, and the typical recommended dose is 300 mg daily starting at the time of orchiectomy with reduction of the dose to 150 mg daily one month later.  Nilutamide is not approved for nor recommended for use in hyperandrogenic states such as hirsutism or acne. 

Side effects of Nilutamide

Common side effects include dizziness, impaired vision, fatigue, nausea and anorexia.

 

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