Information about Nickel
Nickel is a heavy metal and trace element that is active in many chemical reactions, but is not clearly an essential element in humans. No metabolic or biochemical function for nickel has been identified in higher animals, but it is found in many tissues and actively interacts with other metals, vitamins and proteins.
Deficiency of Nickel
Nevertheless, nickel deficiency states have not been identified in humans.
Toxicity of Nickel
Nickel can be toxic at high levels, but is unlikely to occur from dietary sources. Nickel can also cause allergic reactions, particularly dermatologic. There is no evidence that nickel causes liver toxicity.
Trace Elements in Tissues and Biologic Systems