Netupitant

Netupitant

Netupitant (pronounced ne-tu-pi-tant) is a drug used in the prevention of chemotherapy-induced nausea and vomiting (CINV). It is often used in combination with palonosetron and marketed under the brand name Akynzeo.

Etymology

The name "Netupitant" is derived from the drug's chemical structure. The "netu" part of the name is an abbreviation of the chemical name N-ethyl-naphthyl-tetrahydro-pyridine, while the "pitant" part of the name is a common suffix for drugs that act as antagonists.

Pharmacology

Netupitant is a highly selective antagonist of the human substance P/neurokinin 1 (NK1) receptor. It works by blocking the action of substance P, a neurotransmitter in the brain that plays a key role in the vomiting reflex.

Clinical Use

Netupitant is used in combination with palonosetron, a serotonin 5-HT3 receptor antagonist, to prevent acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including highly emetogenic chemotherapy.

Related Terms

• Chemotherapy
• Nausea
• Vomiting
• Palonosetron
• Antagonist
• Neurokinin 1
• Serotonin

External links

• Medical encyclopedia article on Netupitant
• Wikipedia's article - Netupitant

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