Nalmefene

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Nalmefene (pronounced: nal-MEH-feen) is a medication used primarily in the management of alcohol dependence. It is an opioid antagonist, specifically an antagonist of the μ-opioid receptor, and has also been found to act as an antagonist of the κ-opioid receptor and δ-opioid receptor.

Etymology

The term "Nalmefene" is derived from "nally" (an abbreviation of nallyl), "me" (a prefix used in organic chemistry to denote methylation), and "fene" (a suffix used in medicine to denote a type of drug, specifically an opioid antagonist).

Pharmacology

Nalmefene works by binding to the μ-opioid receptor, κ-opioid receptor, and δ-opioid receptor, thereby blocking the effects of opioids. This mechanism of action is what makes it effective in the treatment of alcohol dependence, as it can reduce the rewarding effects of alcohol consumption and thus help individuals reduce their alcohol intake.

Uses

Nalmefene is primarily used in the treatment of alcohol dependence. It is also sometimes used off-label in the treatment of opioid dependence.

Side Effects

Common side effects of Nalmefene include nausea, dizziness, insomnia, and dry mouth. More serious side effects can include severe allergic reactions, hallucinations, and severe nausea and vomiting.

See Also

References

External links

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