Nacolomab tafenatox

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Nacolomab tafenatox (pronunciation: na-co-lo-mab ta-fe-na-tox) is a therapeutic antibody used in the treatment of certain types of cancer. It is a monoclonal antibody that has been conjugated with a toxin, specifically the Pseudomonas exotoxin.

Etymology

The name "Nacolomab tafenatox" is derived from the following components: "Naco" refers to the target antigen (N-acetylglucosaminyltransferase V), "lo" indicates that it is a low-affinity antibody, "mab" is an abbreviation for monoclonal antibody, and "tafenatox" is a reference to the Pseudomonas exotoxin.

Mechanism of Action

Nacolomab tafenatox works by binding to the N-acetylglucosaminyltransferase V antigen on the surface of cancer cells. Once bound, the toxin component of the drug is internalized by the cell, where it inhibits protein synthesis and ultimately leads to cell death.

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