NMDA receptor antagonist

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NMDA Receptor Antagonist

The NMDA receptor antagonist (pronunciation: en-em-dee-ey ree-sep-tor an-tag-o-nist) is a type of medication that inhibits the action of the N-Methyl-D-aspartate receptor (NMDAR).

Etymology

The term "NMDA receptor antagonist" is derived from the name of the receptor it acts upon, the N-Methyl-D-aspartate receptor. The term "antagonist" refers to the drug's ability to block or inhibit the normal function of the receptor.

Function

NMDA receptor antagonists work by binding to the NMDA receptor, thereby blocking the action of glutamate, a neurotransmitter that normally activates the receptor. This action can have various effects on the body, including analgesic effects, neuroprotective effects, and psychoactive effects.

Types of NMDA Receptor Antagonists

There are several types of NMDA receptor antagonists, including phencyclidine (PCP), ketamine, and dextromethorphan (DXM). These drugs have different uses, side effects, and mechanisms of action.

Uses

NMDA receptor antagonists are used in a variety of medical contexts. For example, they are used as anesthetics in both human and veterinary medicine. They are also used in the treatment of certain psychiatric disorders, such as depression and schizophrenia, and in the management of chronic pain.

Side Effects

The side effects of NMDA receptor antagonists can vary depending on the specific drug and the dose used. Common side effects can include hallucinations, dizziness, nausea, and increased heart rate. In some cases, these drugs can also cause serious health problems, such as severe respiratory depression or psychological dependence.

See Also

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