Micronized
Micronized
Micronized (/maɪˈkrɒnaɪzd/), from the Greek words "micro" meaning small and "nizein" meaning to grind, is a term used in the medical and pharmaceutical fields to describe a substance that has been reduced to extremely small particles. The process of micronization is used to increase the surface area of a substance, thereby increasing its solubility and bioavailability.
Process
The process of micronization involves the use of specialized equipment to reduce the size of a substance to a range typically between 1 and 10 micrometers. This is achieved through a variety of methods, including jet milling, ball milling, and high pressure homogenization. The resulting micronized substance has a significantly increased surface area, which can enhance its interaction with the body and improve its therapeutic effects.
Applications
Micronization is commonly used in the pharmaceutical industry to improve the solubility and absorption of poorly soluble drugs. By reducing the particle size of these drugs, they can be more easily absorbed by the body, leading to a more effective treatment. Micronized drugs are often used in oral dosage forms, topical formulations, and inhalation therapies.
In addition to pharmaceuticals, micronization is also used in the production of cosmetics, nutraceuticals, and food additives. In these industries, micronization can improve the texture, taste, and appearance of products, as well as enhance their nutritional value and bioavailability.
Related Terms
- Jet milling: A process used in micronization that involves the use of high-speed jets of compressed air or inert gas to grind particles into a fine powder.
- Ball milling: A method of grinding materials into extremely fine powder, used in micronization.
- High pressure homogenization: A process that uses high pressure to break down particles into smaller sizes, used in micronization.
- Bioavailability: The extent and rate at which a drug or other substance is absorbed and becomes available at the site of action.
External links
- Medical encyclopedia article on Micronized
- Wikipedia's article - Micronized
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