Metronidazole

Information about Metronidazole

Metronidazole is a nitroimidazole derivative bactericidal agent widely used in the treatment of many anaerobic and certain protozoan and parasitic infections.

Liver safety of Metronidazole

Metronidazole has been linked to rare instances of acute, clinically apparent liver injury.

Mechanism of action of Metronidazole

Metronidazole (met" roe nid' a zole) is a nitroimidazole antibiotic that is activated by reduction of its nitro group by susceptible organisms. The activated form of metronidazole is a highly reactive radical anion which targets and damages large protein molecules and DNA. Mammalian cells do not ordinarily activate metronidazole, which accounts for its lack of toxicity in humans.

FDA approval information for Metronidazole

Metronidazole was approved for use in the United States in 1963 and currently several million prescriptions are filled yearly.

Clinical use of Metronidazole

Metronidazole is indicated for treatment and prophylaxis of infections with susceptible anaerobic bacteria and protozoa.

Dosage and administration for Metronidazole

The recommended dosage is 500 to 750 mg taken orally three times daily for 5 to 10 days. Metronidazole is available alone in tablets of 250, 375, 500 and 750 mg as well as in combination with other medications, in multiple generic formulations and under several brand names including Flagyl, Metryl, Noritate, Pylera and Helida. Other formulations include injectable solutions, extended release tablets, suppositories, and topical creams.

Side effects of Metronidazole

The most common side effects include metallic taste, nausea, vomiting, abdominal discomfort and diarrhea.

Antibiotics

Antibacterial agents

• antibacterial agents, classes
  • aminoglycosides, carbapenems, cephalosporins, fluoroquinolones, glycopeptides, macrolide antibiotics, penicillins, sulfonamides,

• • tetracyclines
    • antibacterial agents
  • aztreonam, chloramphenicol, clindamycin, daptomycin, fosfomycin, linezolid, metronidazole, nitrofurantoin, quinupristin-dalfopristin, tedizolid, tinidazole, vancomycin

antitoxins

• bezlotoxumab, obiltoxaximab, raxibacumab

• leishmaniasis agents
  • miltefosine

• antituberculosis agents

leprosy agents

• clofazimine, dapsone, rifampin

Other anti-infective agents

• antiviral agents
• antifungal agents
• antihelmintic agents
• antimalarial agents

Cost and Coupons - Metronidazole

• GoodRx compare cost & coupons for Metronidazole

Reviews for Metronidazole

• Reviews for Metronidazole

This article is a stub. YOU can help Wikimd by expanding it!

WikiMD is a sponsored by W8MD Weight loss, sleep and medical aesthetics.

Articles on Metronidazole

• UpToDate on Metronidazole
• NIH NLH drug info on Metronidazole

Read Wikipedia's article on Metronidazole

Learn more about Metronidazole

• Dailymed label info on Metronidazole
• Scientific articles on Metronidazole
• Images for Metronidazole

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Help WikiMD: Find something you can improve? Join WikiMD as an an editor and help improve the page Metronidazole or others.