Mesalamine

From WikiMD
Jump to navigation Jump to search

Information about Mesalamine

Mesalamine, also known as mesalazine and 5-aminosalicylate, is an orally available, antiinflammatory agent used for the treatment of ulcerative colitis to both induce and maintain remissions in disease.

Liver safety of Mesalamine

Mesalamine therapy has been associated with a low rate of serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury.

Mechanism of action of Mesalamine

Mesalamine (me sal’ a meen) is used to treat disease flares in ulcerative colitis and to maintain disease remission. Mesalamine has antiinflammatory, antioxidant and antimicrobial activity and is locally active in the large intestine in reducing inflammation and injury. Mesalamine appears to act by inhibition of lipooxygenase activity, thereby inhibiting production of leukotrienes and leading to reduction in interleukin 1 (IL-1) and tumor necrosis factor (TNF) alpha.

FDA approval information for Mesalamine

Mesalamine was approved for use in the United States in 1985 and remains a first line agent in the therapy of ulcerative colitis, both for induction and maintenance of clinical remission. It is poorly effective in Crohn disease, its major activity being in the large, rather than the small intestine. Mesalamine by itself is largely absorbed in the small intestine and little reaches the colon. For this reason, it is formulated to avoid absorption in the upper intestine and to be released in active form in the colon. The delayed absorption is accomplished either by enteric coating or by formulation as a pro-drug that is activated in the large intestine by local conditions or bacterial enzymes. Formulations of mesalamine include extended or delayed release formulations (Pentasa, Asacol, Lialda, Apriso) and mesalamine pro-drugs including sulfasalazine, olsalazine and balsalazide.

Dosage and administration for Mesalamine

Typical doses range considerable and vary by preparation, but are generally in the range of 1.5 to 4.8 g of mesalamine daily. Mesalamine is also available as an enema (Rowasa and others) and rectal suppositories (Canasa), which are useful for ulcerative proctitis and in ameliorating symptoms in mildly active, distal ulcerative colitis.

Balsalazide

Balsalazide (bal sal’ a zide) is a pro-drug of mesalamine that consists of 5-aminosalicylate with an azo bond to a phenyl-hydroxybenzoid acid moiety which is cleaved off in the large intestine by bacterial enzymes, releasing free mesalamine. Balsalazide was approved as treatment of mildly to moderately active ulcerative colitis in adults in the United States in 2000 and is available generically and under the brand name Colazal in capsules of 750 mg; the usual dosage being 2.25 to 6.75 g daily in three divided doses.

Olsalazine

Olsalazine (ol sal’ a zeen) is a prodrug of mesalamine that consists of two molecules of 5-aminocsalicylate (5’5’-azodisalicylate) joined at the amino-terminus with an azo bond that is cleaved by bacterial action in the colon, releasing two molecules of mesalamine. Olsalazine was approved in the United States for maintenace of remission of ulcerative colitis in patients intolerant of sulfasalazine in 2007 and is available under the brand name Dipentum in capsules of 250 mg, the usual dose being 500 mg twice daily.

Sulfasalazine

Sulfasalazine (sul" fa sal' a zeen) is a prodrug of mesalamine that consists of 5-aminosalicylate joined with an azo bond to sulfapyridine. Sulfasalazine has been used extensively in the treatment of ulcerative colitis, but adverse reactions to the sulfonamide component of the agent can be problematic and has led to a decline in its use in favor of mesalamine by itself.

Mesalamine

Mesalamine is generally well tolerated and adverse event rates are similar to what is reported with placebo therapy of ulcerative colitis. Side effects may include diarrhea, headache, dizziness and nausea. Hypersensitivity reactions and pancreatitis can occur, but are rare. Template:Gastrointestinal drugs

Cost and Coupons - Mesalamine

Reviews for Mesalamine

This article is a stub. YOU can help Wikimd by expanding it!

Articles on Mesalamine

Wikipedia

Learn more about Mesalamine

Help WikiMD

Find something you can improve? Join WikiMD as an an editor and help improve this page or others.

Apple bitten.svg

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*
Wellness | weight loss portal | Weight loss tips | W8MD's medical weight loss | Lose weight New York City

Philadelphia weight loss | Lose weight King of Prussia | Weight Loss NYC | Brooklyn weight loss | Advertise

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Mesalamine">Mesalamine</a>

  • Individual results may vary for weight loss from our sponsors.