Meprobamate

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Information about Meprobamate

Meprobamate is a sedative used for anxiety and insomnia, which infrequently causes liver enzyme elevations and which has not been linked to instances of clinically apparent liver injury.

Information about Meprobamate

Meprobamate (me" proe bam' ate) is a bis-carbamate ester which was found to have antianxiety activity and was introduced into medical use in the 1950s. Meprobamate rapidly became one of the most widely used psychotropic agents, being considered a “tranquillizer”. Commonly known by its brand name Miltown, it was approved for use in anxiety, but was widely used as a sedative and for insomnia. The sedative effects of meprobamate resemble those of the benzodiazepines, and it is known to bind to the GABA-A receptor. However, the precise mechanism of action of meprobamate is unclear. Meprobamate also has major abuse potential and many cases of dependency, habituation and overdose have been described. Withdrawal can lead to hallucinations and seizures.

FDA approval information for Meprobamate

Meprobamate was approved for use in generalized anxiety disorders in the United States in 1955, but it is currently rarely used and is classified as a Schedule IV controlled substance because of its potential for abuse and dependency. Nevertheless, meprobamate remains available in several generic forms as 200 and 400 mg tablets. In addition, the muscle relaxant carisoprodol is a prodrug of meprobamate and is clinically available, although now it is also classified as a Schedule IV controlled substance [January 2012].

Dosage and administration for Meprobamate

The recommended dosage of meprobamate is 1200 to 1600 mg daily in three or four divided doses.

Side effects of Meprobamate

Side effects may include drowsiness, ataxia, dizziness, headache, weakness, nervousness, euphoria, overstimulation and physical dependence.

Sedatives and Hypnotics

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