Median lethal dose
Median lethal dose (LD50)
Median lethal dose (LD50) is a term used in toxicology to denote the dose of a substance that is lethal to 50% of a population of test organisms. The term is often used to determine the relative toxicity of a substance.
Pronunciation
- Median lethal dose: /ˈmiːdiən ˈliːθəl doʊs/
Etymology
The term "median lethal dose" is derived from the Latin words "medius" (middle), "letalis" (deadly), and "dosis" (a giving or dose). The abbreviation "LD50" stands for "Lethal Dose, 50%" indicating the dose that kills half the population of organisms exposed to it.
Related Terms
- Toxicity: The degree to which a substance can harm humans or animals.
- Dose-response relationship: The relationship between the dose of a drug or toxin and the effect it has on an organism.
- Acute toxicity: The adverse effects of a substance that result either from a single exposure or from multiple exposures in a short period of time.
- Chronic toxicity: The adverse effects of a substance that occur after a long period of exposure.
- Threshold limit value: The recommended maximum concentration of a chemical substance in workplace air to which an employee can be exposed.
See Also
External links
- Medical encyclopedia article on Median lethal dose
- Wikipedia's article - Median lethal dose
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