Malonyl-CoA
Malonyl-CoA
Malonyl-CoA (pronounced: ma-lo-nil ko-a) is a key metabolite in the biochemistry of organisms. It plays a crucial role in fatty acid metabolism and polyketide synthesis.
Etymology
The term "Malonyl-CoA" is derived from the combination of "malonyl", which is a derivative of malonic acid, and "CoA", an abbreviation for Coenzyme A, a coenzyme involved in the synthesis and oxidation of fatty acids.
Role in Metabolism
Malonyl-CoA is a critical intermediate in fatty acid biosynthesis. It is formed by the carboxylation of acetyl-CoA, a reaction catalyzed by the enzyme acetyl-CoA carboxylase. Malonyl-CoA is then used by fatty acid synthase to synthesize long-chain fatty acids.
In addition to its role in fatty acid synthesis, Malonyl-CoA also inhibits the transport of fatty acyl CoAs into the mitochondria by binding to carnitine palmitoyltransferase I, thereby preventing beta-oxidation of fatty acids.
Related Terms
- Acetyl-CoA
- Fatty acid metabolism
- Polyketide
- Coenzyme A
- Acetyl-CoA carboxylase
- Fatty acid synthase
- Carnitine palmitoyltransferase I
- Beta-oxidation
External links
- Medical encyclopedia article on Malonyl-CoA
- Wikipedia's article - Malonyl-CoA
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