Loewe additivity

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Loewe Additivity

Loewe Additivity (pronounced: Loo-ehv Ad-dih-tiv-ih-tee) is a principle in pharmacology that describes the combined effect of two or more drugs. It is named after the German pharmacologist Alfred Loewe, who first proposed the concept in the early 20th century.

Etymology

The term "Loewe Additivity" is derived from the name of its proposer, Alfred Loewe, and the English word "additivity", which refers to the property of a system where the combined effect of two or more factors is equal to the sum of their individual effects.

Definition

Loewe Additivity is a model used to predict the combined effect of two or more drugs. According to this principle, if two drugs are combined and each drug alone has a certain effect, then the combined effect of the two drugs should be equal to the sum of their individual effects. This is also known as the principle of superposition in pharmacology.

Related Terms

  • Synergism: A phenomenon where the combined effect of two or more drugs is greater than the sum of their individual effects.
  • Antagonism: A phenomenon where the combined effect of two or more drugs is less than the sum of their individual effects.
  • Potentiation: A phenomenon where one drug enhances the effect of another drug.
  • Pharmacodynamics: The study of the biochemical and physiological effects of drugs and their mechanisms of action.

See Also

External links

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