Limbal stem cell

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Limbal Stem Cell

Limbal stem cells (pronunciation: /ˈlɪmbəl/ /stɛm/ /sɛl/) are a type of stem cell found in the eye. They are located in the limbus, the border area between the cornea and the sclera, an area rich in blood vessels and cells.

Etymology

The term "limbal" is derived from the Latin word "limbus", meaning border or edge, referring to the location of these cells at the edge of the cornea. The term "stem cell" comes from the fact that these cells serve as a "stem" or source for new cell growth and regeneration.

Function

Limbal stem cells are responsible for maintaining and replenishing the corneal epithelium, the outermost layer of the cornea. They play a crucial role in corneal wound healing and regeneration, and their loss or dysfunction can lead to a condition known as limbal stem cell deficiency (LSCD), which can cause severe vision loss.

Related Terms

  • Cornea: The clear front surface of the eye, which covers the iris and pupil.
  • Sclera: The white outer layer of the eye.
  • Limbus: The border area between the cornea and the sclera.
  • Stem cell: A type of cell with the unique ability to develop into specialized cell types in the body.
  • Limbal stem cell deficiency (LSCD): A condition caused by the loss or dysfunction of limbal stem cells, leading to severe vision loss.

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