Leukotriene

Leukotriene

Leukotrienes (pronounced: loo-ko-try-eens) are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (Arachidonic Acid).

Etymology

The term "leukotriene" (LT) is derived from the source of their discovery, leukocytes, and the fact that they contain three conjugated double bonds (triene).

Function

Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses. Leukotrienes are produced in the body from arachidonic acid by the enzyme 5-lipoxygenase (5-Lipoxygenase).

Types

There are four types of leukotrienes: LTA4, LTB4, LTC4, LTD4, and LTE4. LTB4 is involved in inflammation and immune response, attracting leukocytes to areas of tissue damage. LTC4, LTD4, and LTE4, also known as cysteinyl leukotrienes, are involved in bronchoconstriction, increased vascular permeability, and mucus secretion in asthma and allergies.

Related Terms

• Eicosanoid
• Arachidonic acid
• 5-lipoxygenase
• Inflammation
• Immune response
• Asthma
• Allergies

See Also

• Prostaglandin
• Thromboxane
• Lipoxin

External links

• Medical encyclopedia article on Leukotriene
• Wikipedia's article - Leukotriene

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