Keratohyalin

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Keratohyalin

Keratohyalin (pronunciation: ker·a·to·hy·a·lin) is a type of protein granule found in the stratum granulosum layer of the epidermis. It plays a crucial role in the process of keratinization, which is the transformation of epithelial cells into keratinocytes.

Etymology

The term 'Keratohyalin' is derived from the Greek words 'keras' meaning horn and 'hyalos' meaning glass. This is in reference to the granules' appearance and their role in the formation of the hard, horn-like substance known as keratin.

Function

Keratohyalin granules are responsible for the aggregation of keratin intermediate filaments, which are essential for the formation of the cornified cell envelope (CCE). The CCE is a layer of dead skin cells that serves as a barrier to protect the body from external environmental factors.

Related Terms

  • Stratum granulosum: The layer of the epidermis where keratohyalin is found.
  • Keratinization: The process in which epithelial cells are transformed into keratinocytes.
  • Epithelial cells: The type of cells that are transformed into keratinocytes.
  • Keratinocytes: The cells that make up the majority of the epidermis.
  • Keratin: The protein that is aggregated by keratohyalin granules.
  • Cornified cell envelope (CCE): The layer of dead skin cells that is formed by the aggregation of keratin intermediate filaments.

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