Keratin 14
Keratin 14
Keratin 14 (pronunciation: /kɛrətɪn fɔːrˈtiːn/), also known as KRT14, is a type of keratin protein that is encoded by the KRT14 gene in humans.
Etymology
The term "Keratin" originates from the Greek word "κέρας" (keras), meaning "horn". The number 14 is used to differentiate this specific type of keratin from others in the keratin family.
Function
Keratin 14 is a type of cytoskeletal protein that provides structural support to epithelial cells, which line the surfaces of organs and structures throughout the body. It is particularly important in the skin, where it helps to maintain the strength and flexibility of the epidermis.
Related Terms
- Keratin: A family of fibrous structural proteins, keratin is the key structural material making up hair, nails, feathers, horns, claws, hooves, calluses, and the outer layer of skin among vertebrates.
- Epithelial Cells: Cells that line the surfaces of structures throughout the body, including the skin, blood vessels, organs, and more.
- Cytoskeletal Protein: A type of cellular protein that provides structural support to cells.
Disorders
Mutations in the KRT14 gene can lead to a variety of skin disorders, including Epidermolysis Bullosa Simplex, a condition characterized by fragile skin that blisters easily.
See Also
External links
- Medical encyclopedia article on Keratin 14
- Wikipedia's article - Keratin 14
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