Job
Job's Syndrome
Job's Syndrome (pronounced: jōbz sinˈdrōm), also known as Hyper IgE Syndrome, is a rare, multisystem immunodeficiency disorder. The name "Job's Syndrome" is derived from the biblical character Job, who was afflicted with severe sores and boils.
Definition
Job's Syndrome is characterized by high levels of immunoglobulin E (IgE) in the blood, skin infections, and recurrent lung infections. It is a genetic disorder, caused by mutations in the STAT3 gene.
Symptoms
The symptoms of Job's Syndrome can vary greatly, but often include eczema, skin abscesses, and recurrent pneumonia. Other symptoms may include skeletal and dental abnormalities, and facial features such as a prominent forehead, deep-set eyes, and a broad nose.
Diagnosis
Diagnosis of Job's Syndrome is based on clinical findings, elevated IgE levels, and genetic testing to identify mutations in the STAT3 gene.
Treatment
Treatment for Job's Syndrome is primarily supportive and includes management of skin and lung infections, and treatment of other associated conditions as needed.
Prognosis
The prognosis for individuals with Job's Syndrome can vary. Some individuals may have a normal lifespan with few complications, while others may experience severe, life-threatening infections.
See Also
External links
- Medical encyclopedia article on Job
- Wikipedia's article - Job
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