Intention to treat analysis
Intention to Treat Analysis
Intention to Treat Analysis (ITT Analysis) is a statistical method used in Randomized Controlled Trials (RCTs). It is pronounced as /ɪnˈtɛnʃən tuː triːt əˈnælɪsɪs/. The term originates from the field of Clinical Trials, where it is used to maintain the benefits of randomization.
Definition
Intention to Treat Analysis is a principle of analysis in which all participants in a trial are analyzed as part of the group to which they were assigned, regardless of whether they completed the intervention given to the group. This method is used to prevent potential bias caused by the loss of participants, which may disrupt the random assignment to the treatment groups in a study.
Application
In Clinical Research, ITT analysis is used to maintain the comparability of groups. It is based on the initial treatment intent, not on the treatment eventually administered. ITT analysis is intended to avoid various misleading artifacts that can arise in intervention research such as non-random attrition of participants from the study or crossover.
Related Terms
- Randomized Controlled Trials (RCTs): A type of scientific experiment that aims to reduce bias when testing a new treatment.
- Clinical Trials: Research investigations in which people volunteer to test new treatments, interventions or tests as a means to prevent, detect, treat or manage various diseases or medical conditions.
- Clinical Research: A branch of healthcare science that determines the safety and effectiveness of medications, devices, diagnostic products and treatment regimens intended for human use.
See Also
External links
- Medical encyclopedia article on Intention to treat analysis
- Wikipedia's article - Intention to treat analysis
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