Integrin alphaXbeta2
Integrin alphaXbeta2
Integrin alphaXbeta2 (pronunciation: in-te-grin al-fa eks be-ta too), also known as CD11c/CD18 or complement receptor 4 (CR4), is a protein that in humans is encoded by the ITGAX and ITGB2 genes.
Etymology
The term "Integrin" is derived from the Latin word "integer", meaning "whole" or "entire", reflecting the role of integrins in integrating signals from the extracellular matrix (ECM) to the cell. The alphaXbeta2 nomenclature refers to the specific combination of alpha (X) and beta (2) subunits that make up this particular integrin.
Function
Integrin alphaXbeta2 is a type of leukocyte-specific integrin that plays an essential role in the immune and inflammatory responses. It is involved in various cellular processes, including cell adhesion, cell surface signaling, and phagocytosis of particles.
Related Terms
- Leukocyte: A type of blood cell that is involved in protecting the body against both infectious disease and foreign invaders.
- Extracellular matrix (ECM): A three-dimensional network of extracellular macromolecules, such as collagen, enzymes, and glycoproteins, that provide structural and biochemical support to surrounding cells.
- Phagocytosis: The process by which a cell engulfs a solid particle to form an internal compartment known as a phagosome.
- Cell adhesion: The process by which cells interact and attach to a surface, substrate or another cell, mediated by interactions between molecules of the cell surface.
- Cell surface signaling: The process by which signals are transferred from the cell surface to the interior of the cell, leading to a response.
External links
- Medical encyclopedia article on Integrin alphaXbeta2
- Wikipedia's article - Integrin alphaXbeta2
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