Insulin receptor
Insulin receptor
The Insulin receptor (pronounced as /ˈɪnsjʊlɪn rɪˈsɛptər/) is a transmembrane protein that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.
Etymology
The term "Insulin receptor" is derived from the hormone insulin and the term "receptor" which is from the Latin 'receptus', meaning 'received'.
Function
Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that underlies the pathophysiology of insulin resistance.
Structure
The insulin receptor is a tetramer of two alpha and two beta units. The alpha and beta units are coded by a single gene and are joined by disulfide bonds, a mechanism parallel to that of its ligand, insulin.
Related Terms
See Also
- Insulin-like growth factor
- Insulin-like growth factor 1 receptor
- Insulin-like growth factor 2 receptor
External links
- Medical encyclopedia article on Insulin receptor
- Wikipedia's article - Insulin receptor
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