Incompatibility

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Incompatibility (In-com-pat-i-bil-i-ty)

Incompatibility (pronounced as in-kəm-ˌpa-tə-ˈbi-lə-tē) is a term used in various fields of medicine, including pharmacology, genetics, and immunology. It generally refers to the inability of certain substances or factors to exist or function together without adverse effects.

Etymology

The term "incompatibility" originates from the Latin words "in" (not) and "compatibilis" (compatible), essentially meaning "not compatible".

Pharmacology

In pharmacology, incompatibility refers to the undesirable reaction that occurs between substances when they are mixed together. This can result in a change in the physical or chemical properties of the substances, potentially leading to decreased effectiveness or increased toxicity. Examples of this include the incompatibility between certain antibiotics and intravenous fluids.

Genetics

In genetics, incompatibility can refer to the inability of two organisms to produce viable offspring due to genetic differences. This is often seen in plants, where certain combinations of alleles can result in incompatibility, preventing successful fertilization or development of the offspring.

Immunology

In immunology, incompatibility refers to the reaction that occurs when the immune system of a recipient recognizes a transplanted organ or tissue as foreign. This can lead to transplant rejection, a serious complication that can result in the failure of the transplanted organ or tissue.

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