Inclisiran
Inclisiran (pronounced in-kli-si-ran) is a novel medication used for the treatment of hypercholesterolemia, a condition characterized by high levels of cholesterol in the blood.
Etymology
The name "Inclisiran" is derived from the Latin words 'inclinare' meaning 'to bend' and 'serum' meaning 'blood'. This is in reference to the drug's mechanism of action, which involves altering the lipid profile in the blood.
Pharmacology
Inclisiran is a small interfering RNA (siRNA) that works by inhibiting the production of proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein that plays a crucial role in regulating cholesterol levels in the body. By reducing the levels of PCSK9, Inclisiran allows for greater removal of low-density lipoprotein (LDL) or "bad" cholesterol from the bloodstream.
Usage
Inclisiran is used in conjunction with a healthy diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease who require additional lowering of LDL cholesterol.
Side Effects
Common side effects of Inclisiran include fatigue, hypertension, edema, musculoskeletal pain, and diarrhea.
Related Terms
- Hypercholesterolemia
- RNA
- Proprotein convertase subtilisin/kexin type 9
- Low-density lipoprotein
- Heterozygous familial hypercholesterolemia
- Atherosclerotic cardiovascular disease
External links
- Medical encyclopedia article on Inclisiran
- Wikipedia's article - Inclisiran
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