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Information about Hyoscyamine

Hyoscyamine as a natural plant alkaloid derivative and anticholinergic that is used to treat mild to moderate nausea, motion sickness, hyperactive bladder and allergic rhinitis.

Liver safety of Hyoscyamine

Hyoscyamine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Mechanism of action of Hyoscyamine

Hyoscyamine (hye" oh sye' a meen) is a derivative of natural alkaloid found in plants of the Solanacea family such as henbane (Hyoscyamus niger, for which it is named), jimson weed (Datura stramonium), tomatoes (Soanum lycopersicum) and deadly nightshade (Atropa belladonna). Hyoscyamine is the levorotary isomer of atropine and has potent anticholinergic, antimuscarinic activity. It has been used for decades as an antiemetic, antisecretory and antispasmotic agent in the treatment of nausea, motion sickness, allergic rhinitis, gastrointestinal spasm and hypermotility, functional bowel syndrome and hyperactive bladder.

FDA approval information for Hyoscyamine

Despite having been used in clinical medicine for decades, hyoscyamine has not been formally approved for many of its common uses in the United States.

Dosage and administration for Hyoscyamine

Hyoscyamine is available as tablets, capsules, liquids, elixirs, powders, and solutions for injection in both prescription and over-the-counter forms.

Brand name for Hyoscyamine

Common brand names for products that include hyoscyamine are Belladonna Alkaloids, Donnatal, Hyomax, Urogesic, and Cyclospaz.

Dosage and administration for Hyoscyamine

The recommended adult oral dose varies, but is generally 0.125 to 0.25 mg two to four times daily.

Side effects of Hyoscyamine

Common side effects are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, headache, visual blurring, constipation, urinary retention, impotence, tachycardia and palpitations, anxiety, restlessness and in some instances agitation and hallucinations. anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention.

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