W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
29,050 pages, 4,107,681 edits & 35,855,462 views.

Free unbiased diet, health and wellness info!

Hydroxyurea

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Hydroxyurea

Hydroxyurea is an antimetabolite that is used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease.   

Hydroxyurea
Hydroxyurea

Liver safety of Hydroxyurea

Hydroxyurea is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice.

Mechanism of action of Hydroxyurea

Hydroxyurea (hye drox” ee ure ee’ a) is a hydroxylated analogue of urea and an antimetabolite which inhibits the enzyme ribonucleotide reductase, which is necessary for DNA synthesis and cell cycle replication.  Blocking the enzyme results in cell cycle arrest in the S phase, but does not interfere with RNA or protein synthesis.  Hydroxyurea is used in the treatment of solid tumors and myeloproliferative diseases, the latter because of its effects in reducing excessive production of red blood cells (polycythemia vera), white blood cells (chronic myelogenous leukemia) or platelets (essential thrombocythemia).  Hydroxyurea also increases the production of fetal hemoglobin, via an unknown mechanism of action, which increases overall hemoglobin levels and decreases sickling in patients with sickle cell anemia.  In controlled clinical trials, hydroxyurea has been shown to increase hemoglobin concentrations, decrease transfusion requirements and lessen painful crises in patients with sickle cell disease. 

FDA approval information for Hydroxyurea

Hydroxyurea was first approved for use in the United States in 1967 as an antineoplastic agent for therapy of melanoma, chronic myelogenous leukemia, ovarian carcinoma, and head and neck cancers.  The indications were expanded to sickle cell disease in 1998, which is the major indication for its use at present. 

Dosage and administration for Hydroxyurea

Hydroxyurea is available in capsules of 200, 300, 400 and 500 mg generically and under brand names as Droxia (for sickle cell disease) and Hydrea (for cancer).  The usual dose in sickle cell disease is 15 mg/kg/day, with subsequent dose adjustments based upon efficacy and tolerance.  Higher doses are used in cancer chemotherapy. 

Side effects of Hydroxyurea

Common side effects include bone marrow suppression (particularly thrombocytopenia), nausea, vomiting, anorexia, diarrhea, mucositis, hair loss, headache, rash and fever.  Uncommon, but potentially severe adverse reactions include severe skin ulcers, neuropathy, renal dysfunction, severe bone marrow suppression and pulmonary fibrosis.  Long term hydroxyurea therapy may increase the risk of cancer.

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Hydroxyurea

Reviews for Hydroxyurea

Learn more about Hydroxyurea

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Hydroxyurea is a stub.
If you are a healthcare professional familiar with the topic Hydroxyurea, or
A subject matter expert or authority on Hydroxyurea, you can help us.
About | Mission | Paid editors welcome!

Hydroxyurea is part of WikiMD's ^articles available 4free, 4all & 4ever!
^The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional advice
WIKIMD MAKES NO GUARANTEE OF VALIDITY OF CONTENT. USE THE CONTENT AT YOUR OWN RISK!

A very small portion of the content such as templates etc., when imported from wikipedia, are licensed under CC BY-SA 3.0. ^See full disclaimers and terms of use

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.