Hycanthone
Hycanthone
Hycanthone (pronounced: hi-KAN-thone) is a anthelmintic drug that was primarily used in the treatment of schistosomiasis, a disease caused by parasitic worms.
Etymology
The term 'Hycanthone' is derived from the chemical name Hydroxy cantharidin one.
Usage
Hycanthone was used as an anthelmintic agent, particularly effective against Schistosoma mansoni, a species of trematodes, commonly known as schistosomes. However, due to its potential to cause mutagenesis and carcinogenesis, its use has been discontinued in many countries.
Mechanism of Action
Hycanthone inhibits the activity of the enzyme DNA topoisomerase II, which is essential for DNA replication and transcription. This leads to the death of the parasite.
Side Effects
Common side effects of Hycanthone include nausea, vomiting, abdominal pain, and dizziness. Severe side effects may include hepatotoxicity and neurotoxicity.
Related Terms
- Anthelmintic: A type of drug that expels parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them.
- Schistosomiasis: A disease caused by infection with freshwater parasitic worms in certain tropical and subtropical countries.
- DNA topoisomerase II: An enzyme that helps in the winding and unwinding of DNA during replication and transcription.
External links
- Medical encyclopedia article on Hycanthone
- Wikipedia's article - Hycanthone
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