Histamine intolerance

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Histamine Intolerance

Histamine intolerance (pronunciation: his-tuh-meen in-tol-er-uhns) is a condition that affects certain individuals who have a reduced ability or inability to break down histamine, a compound that is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

Etymology

The term "histamine" is derived from the Greek words "histos" meaning tissue, and "amine" a type of organic compound. "Intolerance" comes from the Latin "intolerantia", meaning "impatience, insensitivity, intolerance".

Definition

Histamine intolerance is not a sensitivity to histamine, but an indication that the body has too much histamine. Histamine levels in the body are generally regulated by two enzymes: diamine oxidase (DAO) and histamine N-methyltransferase (HNMT). When either of these enzymes is deficient or inhibited, the breakdown of histamine is impaired, leading to an excess of histamine in the body, which can cause a variety of symptoms.

Symptoms

Symptoms of histamine intolerance can vary greatly among individuals, but may include headaches, hives, flushing, low blood pressure, irregular heart rate, anxiety, nausea, vomiting, and abdominal cramps. These symptoms can often mimic those of an allergic reaction, leading to confusion and misdiagnosis.

Causes

Histamine intolerance can be caused by a number of factors, including genetic predisposition, gastrointestinal disorders, such as leaky gut syndrome and small intestinal bacterial overgrowth (SIBO), and the consumption of histamine-rich foods or drinks.

Treatment

Treatment for histamine intolerance typically involves a combination of dietary changes, supplementation with DAO, and addressing any underlying health issues that may be contributing to the problem. It is recommended to consult with a healthcare professional for a proper diagnosis and treatment plan.

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