Heparin necrosis
Heparin Necrosis
Heparin necrosis (/hɪˈpærɪn nɪˈkrəʊsɪs/) is a rare complication that can occur following the administration of heparin, an anticoagulant medication. The term "necrosis" refers to the death of cells or tissues.
Etymology
The term "heparin" is derived from the Greek word "hepar," which means liver, as it was first isolated from dog liver. "Necrosis" is derived from the Greek word "nekrosis," meaning death.
Definition
Heparin necrosis is a condition characterized by the death of skin tissue (necrosis) that occurs after the injection of heparin. This condition is typically associated with a paradoxical thrombotic state, despite the anticoagulant properties of heparin.
Symptoms
Symptoms of heparin necrosis include skin discoloration, pain at the injection site, and the development of skin lesions. In severe cases, it can lead to skin ulceration and gangrene.
Causes
Heparin necrosis is caused by the administration of heparin, particularly in high doses. It is more common in patients with certain risk factors, such as those with a history of thrombocytopenia or protein C deficiency.
Treatment
Treatment for heparin necrosis involves discontinuing the use of heparin and switching to an alternative anticoagulant. In severe cases, surgical intervention may be required to remove necrotic tissue.
Related Terms
External links
- Medical encyclopedia article on Heparin necrosis
- Wikipedia's article - Heparin necrosis
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