Gonadotropin insensitivity
Gonadotropin Insensitivity
Gonadotropin insensitivity (pronunciation: go-nad-o-tro-pin in-sen-si-tiv-ity) is a medical condition characterized by the body's resistance to the effects of gonadotropins, a type of hormone that plays a crucial role in sexual development and reproduction.
Etymology
The term "gonadotropin" is derived from the Greek words "gonos" meaning seed and "tropos" meaning turn, referring to the hormone's role in directing the function of the gonads. "Insensitivity" comes from the Latin "insensibilis", meaning unfeeling or insensitive, referring to the body's lack of response to the hormone.
Definition
Gonadotropin insensitivity is a condition where the body's cells are unresponsive to the hormones LH and FSH, collectively known as gonadotropins. These hormones are produced by the pituitary gland and are essential for normal sexual development and reproductive function.
Symptoms
Symptoms of gonadotropin insensitivity can vary greatly depending on the severity of the condition. They may include delayed or absent puberty, infertility, and in severe cases, underdeveloped sexual characteristics.
Causes
Gonadotropin insensitivity is usually caused by mutations in the genes that encode the receptors for LH and FSH. These mutations can prevent the receptors from functioning properly, leading to a lack of response to the hormones.
Treatment
Treatment for gonadotropin insensitivity typically involves hormone replacement therapy to compensate for the body's lack of response to LH and FSH. This can help to induce puberty and promote normal sexual development.
Related Terms
- Gonadotropin
- Luteinizing hormone
- Follicle-stimulating hormone
- Pituitary gland
- Hormone replacement therapy
External links
- Medical encyclopedia article on Gonadotropin insensitivity
- Wikipedia's article - Gonadotropin insensitivity
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