Liver safety of Gentamicin
Despite its wide use, gentamicin has not been definitively linked to instances of clinically apparent liver injury.
Mechanism of action of Gentamicin
gentamicin (jen" ta mye' sin) is a aminoglycoside with broad bacteriocidal activity against many aerobic gram negative and some aerobic gram positive organisms. gentamicin is the most commonly used aminoglycoside antibiotic and is indicated for moderate-to-severe bacterial infections caused by sensitive agents, primarily gram negative bacteria. Like other aminoglycosides, gentamicin is thought to act by binding to bacterial ribosomes and inhibiting protein synthesis. Nevertheless, gentamicin is considered bacteriocidal as well as bacteriostatic. Gentamicin and other aminoglycosides are typically used in combination with a penicillin or cephalosporin for treatment of severe infections with E.Coli, Staphylococcus aureus, Enterobacter, Klebsiella, Serratia, Pseudomonas aeruginosa, and other gram negative bacteria resistant to less toxic antibiotics. Gentamicin is most commonly used for septicemia, bacterial endocarditis, peritonitis, meningitis, pelvic inflammatory disease and pneumonia.
FDA approval information for Gentamicin
Gentamicin was first approved for use in the United States in 1970 and remains in wide use.
Dosage and administration for Gentamicin
Gentamicin is available in multiple generic parenteral formulations and the typical adult dose is 3 to 5 mg/kg per day im or iv, usually in three divided doses and often after a loading dose. Doses must be modified based upon renal function and monitoring of drug levels is advisable. Topical formulations are also available for local wound, tissue and ophthalmologic anti-bacterial therapy.
Side effects of Gentamicin
Common side effects of gentamicin include dizziness, headache, confusion, nausea and skin rash. Important, dose related adverse effects include oto- and nephrotoxicity, which are shared by all aminoglycosides.
List of aminoglycosides