Generalized pustular psoriasis

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Generalized pustular psoriasis (pronunciation: jen-er-uh-lahyzd pus-chuh-lar suh-rye-uh-sis) is a rare and severe form of psoriasis that can be life-threatening, especially in older people. It is characterized by widespread areas of reddened skin, which become covered with small sterile pustules.

Etymology

The term "generalized pustular psoriasis" is derived from the Latin generalis (pertaining to the whole), the Latin pustula (a blister or pimple), and the Greek psoriasis (itching condition or being itchy).

Symptoms

Symptoms of generalized pustular psoriasis include fever, chills, severe itching, rapid pulse rate, exhaustion, anemia, weight loss and muscle weakness. The skin becomes bright red and looks like it's been scalded. Within hours, the pustules appear. Over the next day or so, the pustules dry and peel off, leaving the skin shiny and smooth.

Causes

The exact cause of generalized pustular psoriasis is unknown. However, it is thought to be related to genetic and environmental factors. Triggers may include sudden withdrawal from systemic corticosteroids, infection, stress, exposure to certain chemicals and drugs, and exposure to UV light.

Treatment

Treatment for generalized pustular psoriasis includes hospitalization, rehydration, and topical and systemic treatment. Systemic treatments include cyclosporine, methotrexate, and biologics.

Related Terms

See Also

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