Gene targeting
Gene Targeting
Gene targeting (pronunciation: /dʒiːn ˈtɑːrɡɪtɪŋ/) is a genetic technique that uses Homologous recombination to modify an endogenous gene. The method can be used to delete a gene, remove exons, add a gene, or introduce point mutations.
Etymology
The term "gene targeting" is derived from the English words "gene", which comes from the Greek word "genea" meaning generation or race, and "targeting", which means to select as an object of attention or attack.
Process
Gene targeting is a type of genetic modification that involves the alteration of an endogenous gene in a cell to create a mutation. This is achieved by creating a construct where the natural gene can be replaced by the altered gene through homologous recombination. The construct is then inserted into stem cells from an organism. These stem cells are then inserted back into the organism, where they can develop into any type of cell, including germ cells which can pass the mutation on to future generations.
Applications
Gene targeting has been used in research to understand the role of specific genes in health and disease. It is also being explored as a potential method for gene therapy, where it could be used to correct genetic defects.
Related Terms
External links
- Medical encyclopedia article on Gene targeting
- Wikipedia's article - Gene targeting
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