Gene regulatory network
Gene Regulatory Network
A Gene Regulatory Network (GRN) (pronounced: /dʒiːn rɪˈgjʊlətɔːri nɛtwɜːrk/) is a collection of DNA segments in a cell which interact with each other and with other substances in the cell, thereby governing the rates at which genes in the network are transcribed into mRNA.
Etymology
The term "Gene Regulatory Network" is derived from the English words "gene" (from the Greek "genos" meaning race, kind), "regulatory" (from the Latin "regulare" meaning to rule, direct), and "network" (from the Old English "netweorc" meaning work done in a net-like manner).
Definition
A Gene Regulatory Network is a system of intracellular interactions which control gene expression within a cell or a group of cells. These networks are a method of describing the connections and interactions between genes and the products they create, such as proteins and RNA molecules.
Related Terms
- Transcription factor: A protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
- Promoter (genetics): A region of DNA that initiates transcription of a particular gene.
- Operon: A functioning unit of genomic DNA containing a cluster of genes under the control of a single promoter.
- Epigenetics: The study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.
See Also
External links
- Medical encyclopedia article on Gene regulatory network
- Wikipedia's article - Gene regulatory network
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