GLP-1

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GLP-1

GLP-1 (Glucagon-Like Peptide-1, /ˌɡluːkəˈɡɒn laɪk ˈpeptɪd wʌn/) is a peptide hormone that is secreted by the L cells of the small intestine and colon in response to food intake. It is a potent stimulator of insulin secretion and has several other physiological effects that are beneficial for glucose homeostasis and cardiovascular health.

Etymology

The term GLP-1 is derived from its similarity to the hormone glucagon. Both hormones are produced from the same precursor molecule, proglucagon, but have different effects on the body. The "-1" in GLP-1 refers to the fact that it is one of two major bioactive peptides derived from proglucagon, the other being GLP-2.

Function

GLP-1 has several important functions in the body. It stimulates the pancreas to produce and release insulin, a hormone that helps regulate blood sugar levels. It also inhibits the secretion of glucagon, a hormone that raises blood sugar levels. In addition, GLP-1 slows down the rate at which food leaves the stomach, which helps to control appetite and prevent overeating.

Related Terms

  • Insulin: A hormone that regulates the amount of glucose in the blood.
  • Glucagon: A hormone that works with insulin to regulate blood sugar levels.
  • L cells: Cells in the small intestine and colon that secrete GLP-1.
  • Proglucagon: The precursor molecule from which GLP-1 is derived.
  • GLP-2: Another peptide hormone derived from proglucagon.

See Also

External links

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