Fomepizole
Fomepizole
Fomepizole (pronounced fo-MEP-i-zole) is a medical drug used primarily as an antidote in the treatment of methanol and ethylene glycol poisoning.
Etymology
The term "Fomepizole" is derived from its chemical name, 4-methylpyrazole.
Usage
Fomepizole works by inhibiting the enzyme alcohol dehydrogenase, which is necessary for the metabolism of ethylene glycol and methanol to their toxic metabolites. By blocking this enzyme, Fomepizole prevents the formation of these toxic metabolites and allows the body to safely excrete the unmetabolized parent compounds in the urine.
Dosage
The dosage of Fomepizole varies depending on the severity of the poisoning and the patient's weight. It is typically administered intravenously, and the treatment course may last several days until blood levels of the toxic compounds have dropped to safe levels.
Side Effects
Common side effects of Fomepizole include headache, nausea, and dizziness. More serious side effects, such as allergic reactions, are rare but can occur.
Related Terms
External links
- Medical encyclopedia article on Fomepizole
- Wikipedia's article - Fomepizole
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