Fluticasone furoate

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Fluticasone Furoate

Fluticasone furoate (/fluːˈtɪkəsoʊn ˈfjʊəroʊeɪt/) is a synthetic corticosteroid derived from fluticasone, used to treat non-infectious rhinitis (including hay fever and other allergies), and helps to reduce inflammation, swelling and irritation in the nose.

Etymology

The term "fluticasone furoate" is derived from its chemical structure. "Fluticasone" is a combination of "fluorine", a chemical element that increases the steroid's potency, and "corticosterone", a natural steroid hormone produced by the adrenal glands. "Furoate" refers to the furoic acid ester functional group in its chemical structure.

Pharmacology

Fluticasone furoate is a glucocorticoid receptor agonist. The exact mechanism of action of fluticasone furoate is not known. It is thought to act by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at the cellular level.

Medical Uses

Fluticasone furoate is used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is also used as a nasal spray to treat allergic rhinitis and nasal polyps.

Side Effects

Common side effects of fluticasone furoate include headache, throat irritation, nasal dryness, sneezing, and nosebleed. More serious side effects may include allergic reactions, weakened immune system leading to infection, adrenal insufficiency, and bone loss over time.

Related Terms

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