Fludarabine

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Fludarabine

Fludarabine (pronounced /fluːˈdærəbiːn/) is a chemotherapy medication used to treat hematological malignancies such as chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma, and acute myeloid leukemia (AML). It is a purine analog, which interferes with DNA synthesis and repair.

Etymology

The term "Fludarabine" is derived from the compound's chemical structure, which is a fluorinated derivative of the nucleoside analog vidarabine.

Usage

Fludarabine is primarily used in the treatment of chronic lymphocytic leukemia, non-Hodgkin lymphoma, and acute myeloid leukemia. It is often used in combination with other chemotherapy medications.

Mechanism of Action

Fludarabine is a purine analog, which means it mimics the structure of purine bases, the building blocks of DNA. Once inside the cell, fludarabine is converted into its active form, fludarabine triphosphate. This active form interferes with DNA synthesis and repair, leading to cell death.

Side Effects

Common side effects of fludarabine include nausea, vomiting, and myelosuppression. More serious side effects can include neurotoxicity and pulmonary toxicity.

Related Terms

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