Fludarabine
== Information about Fludarabine == Fludarabine is a purine analogue and antineoplastic agent used in the therapy of chronic lymphocytic leukemia (CLL) and in immunosuppressive regimens in preparation of hematopoietic cell transplantation (HCT).
Liver safety of Fludarabine
Fludarabine is associated with a low rate of transient serum enzyme elevations during therapy and has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. Fludarabine has potent immunosuppressive activity and has been associated with many cases of reactivation of hepatitis B.
Mechanism of action of Fludarabine
Fludarabine (floo dar' a been) phosphate is a purine analogue that is used commonly in the treatment of chronic lymphocyte leukemia. Fludarabine phosphate is a fluorinated derivative of the antiviral agent adenine arabinoside monophosphate (2-fluoro-ara-AMP). Fludarabine is converted intracellularly to the active triphosphate, which competes with adenine triphosphate for use by DNA polymerase leading to inhibition of DNA synthesis.
FDA approval information for Fludarabine
Fludarabine was found to have activity against several forms of leukemia and lymphoma and was approved for use as an antineoplastic agent in the United States in 1991. Current indications are therapy of chronic lymphocyte leukemia. Fludarabine is also used off-label for hairy cell leukemia, mycosis fungoides, and both Hodgkin and non-Hodgkin lymphomas as well as in immunosuppressive regimens for nonmyeloablative hematopoietic cell transplantation (HCT).
Dosage and administration for Fludarabine
Fludarabine is available as a powder or solution for injection generically and under the trade name Fludara. Oral formulations are also available as tablets of 10 mg generically and under the trade name Oforta. The typical adult dose for CLL is 25 mg/m2 intravenously or 40 mg/m2 orally each day for 5 days; each 5 day course given is every 28 days. The dose regimen for nonmyeloablative HCT is typically 30 mg/m2 intravenously for 3 days in the week before transplant, usually in combination with total body irradiation or other alkylating agents.
Side effects of Fludarabine
Common side effects include bone marrow suppression, leucopenia, infections, fever, nausea, vomiting, anorexia, diarrhea, headache, fatigue and skin rash.
Dosage and administration for Fludarabine
FDA approval information for Fludarabine
Side effects of Fludarabine
The article on Fludarabine is a stub. YOU can help Wikimd by expanding it!
Medication resources
Learn more
About WikiMD
About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.
Our mission: Provide up to date physician reviewed health, nutrition and wellness information for free in over 100 languages.
Join us: This article is a stub. Help improve Fludarabine or others. Do not trust amateurs with your life! Join us in this effort!. Paid editors welcome.
 Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP* |
Quick links: Medicine Portal | Encyclopedia | Gray's Anatomy | Topics | Diseases | Drugs | Wellness | Obesity | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Fludarabine">Fludarabine</a>
- Individual results may vary for weight loss from our sponsors.