Fesoterodine

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Information about Fesoterodine

Fesoterodine is an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome.

Liver safety of Fesoterodine

Fesoterodine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Mechanism of action of Fesoterodine

Fesoterodine (fes" oh ter' oh deen) is anticholinergic agent which blocks the muscarinic acetylcholine receptors, particularly those found in the smooth muscle of the bladder. Fesoterodine increases bladder capacity and decreases bladder contractions and the urgency of urination. Fesoterodine is formulated in an extended release formulation and has a quarternary ammonium group that makes it less likely to cross the blood brain barrier.

FDA approval information for Fesoterodine

Fesoterodine was approved for use in the United States in 2008, and indications include urinary urge incontinence and overactive bladder syndrome.

Dosage and administration for Fesoterodine

Fesoterodine is available in tablets of 4 and 8 mg under the brand name Toviaz. The recommended adult oral dose is 4 to 8 mg once daily.

Side effects of Fesoterodine

Common side effects are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, headache, visual blurring, constipation, and urinary retention. Because of its structure, fesoterodine is believed to be less likely than other anticholinergic agents to cause central nervous system effects such as restlessness, confusion and hallucinations. anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention.


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