Feingold syndrome
Feingold Syndrome
Feingold syndrome (pronounced: fayn-gold sin-drome), also known as Oculo-digito-esophageal-duodenal syndrome (ODED), is a rare, genetic disorder characterized by specific abnormalities of the fingers and toes, gastrointestinal tract, and other parts of the body.
Etymology
The syndrome is named after Murray Feingold, a Canadian-American physician who first described the condition in 1975.
Symptoms
Feingold syndrome is characterized by several symptoms, including:
- Microcephaly: A condition where the head is smaller than normal.
- Syndactyly: The fusion of two or more digits.
- Brachydactyly: Shortness of the fingers and toes.
- Esophageal atresia: A condition in which the esophagus does not develop properly.
- Duodenal atresia: A condition in which the first part of the small bowel (the duodenum) has not developed properly.
- Intellectual disability: Reduced ability to understand new or complex information and to learn and apply new skills.
Causes
Feingold syndrome is caused by mutations in the MYCN gene. This gene provides instructions for making a protein that plays a crucial role in the development of many parts of the body.
Diagnosis
Diagnosis of Feingold syndrome is based on a clinical evaluation, a detailed patient history, and specialized tests. Genetic testing can confirm a diagnosis.
Treatment
Treatment of Feingold syndrome is symptomatic and supportive. This may include surgery to correct physical abnormalities, special education for those with intellectual disabilities, and other medical, social, and/or vocational services.
Prognosis
The prognosis for individuals with Feingold syndrome varies. Some individuals may have mild symptoms and a normal lifespan, while others may have severe complications.
See Also
External links
- Medical encyclopedia article on Feingold syndrome
- Wikipedia's article - Feingold syndrome
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