Factor viii
Factor VIII
Factor VIII (pronounced: Factor Eight) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, Factor VIII is encoded by the F8 gene. Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder.
Etymology
The term "Factor VIII" is derived from the classification of blood clotting factors, where it was identified as the eighth factor necessary for proper blood coagulation.
Function
Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. It is inactive when it is produced and released into the bloodstream, where it binds to von Willebrand factor until an injury that involves blood vessels occurs.
Related Terms
- Hemophilia A: A genetic deficiency in clotting Factor VIII, which causes increased bleeding and usually affects males.
- von Willebrand factor: A blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome.
- Coagulation: The process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair.
See Also
External links
- Medical encyclopedia article on Factor viii
- Wikipedia's article - Factor viii
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