Eszopiclone

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Information about Eszopiclone

Eszopiclone is a benzodiazepine receptor agonist that is used for the treatment of insomnia.

Liver safety of Eszopiclone

Eszopiclone has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.

Mechanism of action of Eszopiclone

Eszopiclone (es zoe' pi klone) is a non-benzodiazepine, benzodiazepine receptor agonist of the cyclopyrrolone class that acts by binding to the benzodiazepine (BZ) site on the GABA receptor complex, causing neural inhibition and helping to induce sleep. Eszopiclone has selectivity for certain BZ receptor subtypes, and does not have the neuromuscular relaxation or anticonvulsant effects of the standard benzodiazepines. Eszopiclone has a relatively short half life and rapid onset of action. In multiple placebo controlled trials, eszopiclone was shown to decrease the latency to onset of sleep and improve perceived sleep quality, with few next day residual effects and minimal evidence of rebound insomnia after withdrawal. Eszopiclone is the S-isomer of zopiclone that has been available in other countries for more than 20 years. Eszopiclone was approved for use in the United States in 2004 for the treatment of insomnia and remains in common use.

Dosage and administration for Eszopiclone

Eszopiclone is available in 1, 2 and 3 mg tablets generically and under the brand name Lunesta.

Dosage and administration for Eszopiclone

The recommended dose is 1 to 3 mg taken orally immediately before bedtime.

DEA controlled substance classification of Eszopiclone

Like the other benzodiazepine receptor agonists, eszopiclone is classified as a Schedule IV controlled substance (low potential for abuse and limited physical or psychological dependence).

Side effects of Eszopiclone

Side effects are uncommon, usually mild and may include unpleasant taste (bitter), headache, nausea, dizziness, dry mouth and drowsiness.

Sedatives and Hypnotics

Miscellaneous Agents

 

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